Segment and Other Information - Summary of Reconciliations of Segment Operating Income (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Segment operating income:
Operating income	$ 194,317	$ (160,018)
Amortization and step-up:
Intangible amortization expense	(89,260)	(66,369)
Inventory step-up expense	(27,201)	(911)
Share-based compensation	(47,300)	(61,166)
Interest expense, net	(21,256)	(13,460)
Depreciation	(5,852)	(4,451)
Acquisition/divestiture-related costs	(1,589)	(49,391)
Manufacturing plant start-up costs	(807)
Restructuring and realignment costs	(537)	(6,093)
Upfront and milestone payments related to license and collaboration agreements		(3,000)
Impairment of long-lived asset		(12,371)
Foreign exchange gain (loss)	420	(848)
Other (expense) income, net	(742)	3,224
Income (loss) before benefit for income taxes	172,739	(171,102)
Orphan [Member]
Segment operating income:
Operating income	351,514	1,054
Inflammation [Member]
Segment operating income:
Operating income	$ 15,349	$ 42,680