Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income (loss)	$ 204,261	$ (123,351)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Depreciation and amortization expense	95,112	70,820
Equity-settled share-based compensation	47,300	61,166
Acquired in-process research and development expense	2,000
Amortization of debt discount and deferred financing costs	1,577	773
Impairment of long-lived asset		12,371
Deferred income taxes	(33,896)	(28,771)
Foreign exchange and other adjustments	1,190	(5,440)
Changes in operating assets and liabilities:
Accounts receivable	(51,665)	224,575
Inventories	(785)	(13,660)
Prepaid expenses and other current assets	(33,205)	(65,575)
Accounts payable	36,067	993
Accrued trade discounts and rebates	47,279	(28,736)
Accrued expenses and other current liabilities	(113,775)	(111,963)
Other non-current assets and liabilities	14,331	3,070
Net cash provided by (used in) operating activities	215,791	(3,728)
CASH FLOWS FROM INVESTING ACTIVITIES:
Payment related to license agreement	(25,000)
Purchases of property, plant and equipment	(14,198)	(18,333)
Payments for acquisitions, net of cash acquired	(3,122)	(2,707,358)
Receipts (payments) for long-term investments, net	1,596	(3,808)
Net cash used in investing activities	(40,724)	(2,729,499)
CASH FLOWS FROM FINANCING ACTIVITIES:
Net proceeds from term loans		1,577,612
Repayment of term loans	(4,000)
Proceeds from the issuance of ordinary shares in connection with stock option exercises	9,071	19,843
Payment of employee withholding taxes relating to share-based awards	(115,108)	(128,261)
Net cash (used in) provided by financing activities	(110,037)	1,469,194
Effect of foreign exchange rate changes on cash, cash equivalents and restricted cash	(1,921)	(3,998)
Net increase (decrease) in cash, cash equivalents and restricted cash	63,109	(1,268,031)
Cash, cash equivalents and restricted cash, beginning of the period	1,584,156	2,083,479
Cash, cash equivalents and restricted cash, end of the period	1,647,265	815,448
SUPPLEMENTAL CASH FLOW INFORMATION:
Cash paid for interest	28,095	18,988
Cash paid for income taxes, net of refunds received	1,496	1,201
Cash paid for amounts included in the measurement of operating lease liabilities	2,208	2,084
SUPPLEMENTAL NON-CASH FLOW INFORMATION:
Purchases of property, plant and equipment included in accounts payable and accrued expenses and other current liabilities	$ 3,627	10,523
Milestone payments for TEPEZZA intangible asset included in accrued expenses and other current liabilities		$ 69,962