X0306 4 2022-01-04 0 0001492426 Horizon Therapeutics Public Ltd Co HZNP 0001366227 McHugh Miles W C/O HORIZON THERAPEUTICS PLC, 70 SAINT STEPHEN?S GREEN DUBLIN L2 D02 E2X4 IRELAND 0 1 0 0 Sr VP & Princ. Acctg Officer Ordinary Shares 2022-01-05 4 M 0 18289 A 54810 D Ordinary Shares 2022-01-05 4 F 0 8175 101.84 D 46635 D Restricted Stock Units (RSU) 2022-01-04 4 A 0 7617 0.00 A Ordinary Shares 7617 7617 D Restricted Stock Units (RSU) 2021-01-05 4 M 0 8992 0.00 D Ordinary Shares 8992 0 D Restricted Stock Units (RSU) 2021-01-05 4 M 0 5805 0.00 D Ordinary Shares 5805 5806 D Restricted Stock Units (RSU) 2021-01-05 4 M 0 3492 0.00 D Ordinary Shares 3492 6986 D Each RSU represents a contingent right to receive one ordinary share of the Issuer. The RSU's vest 1/3rd annually on each anniversary of January 5, 2022. The RSU's vest 1/3rd annually on each anniversary of January 5, 2019. The RSU's vest 1/3rd annually on each anniversary of January 5, 2020. The RSU's vest 1/3rd annually on each anniversary of January 5, 2021. /s/ Miles W. McHugh 2022-01-06