Segment and Other Information - Summary of Net Sales by Medicine (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Segment Reporting Information [Line Items]
Total net sales	$ 3,629,044	$ 3,226,410	$ 2,200,429
TEPEZZA [Member]
Segment Reporting Information [Line Items]
Total net sales	1,965,711	1,661,299	820,008
KRYSTEXXA [Member]
Segment Reporting Information [Line Items]
Total net sales	716,167	565,452	405,849
RAVICTI [Member]
Segment Reporting Information [Line Items]
Total net sales	325,652	291,945	261,615
PROCYSBI [Member]
Segment Reporting Information [Line Items]
Total net sales	209,990	189,965	170,102
UPLIZNA [Member]
Segment Reporting Information [Line Items]
Total net sales	154,622	60,805
ACTIMMUNE [Member]
Segment Reporting Information [Line Items]
Total net sales	126,080	117,164	118,834
PENNSAID 2% [Member]
Segment Reporting Information [Line Items]
Total net sales	73,774	191,621	178,011
RAYOS [Member]
Segment Reporting Information [Line Items]
Total net sales	41,882	56,851	71,811
BUPHENYL [Member]
Segment Reporting Information [Line Items]
Total net sales	7,332	7,860	10,549
DUEXIS [Member]
Segment Reporting Information [Line Items]
Total net sales	4,901	74,023	125,331
VIMOVO [Member]
Segment Reporting Information [Line Items]
Total net sales	1,851	8,397	37,621
QUINSAIR [Member]
Segment Reporting Information [Line Items]
Total net sales	$ 1,082	$ 1,028	$ 698