Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	$ 521,482	$ 534,491	$ 389,796
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization expense	390,393	353,751	279,451
Equity-settled share-based compensation	182,100	219,086	146,627
Impairment of goodwill	56,171
Acquired IPR&D and milestones	52,250	70,072	77,517
Deferred income taxes	49,814	(101,016)	(33,453)
Amortization of debt discount and deferred financing costs	7,912	5,189	12,640
Impairment of long-lived asset		12,371
Loss on debt extinguishment			31,856
Gain on sale of assets		(2,000)	(4,883)
Foreign exchange and other adjustments	9,700	5,067	1,812
Changes in operating assets and liabilities:
Accounts receivable	(43,457)	34,796	(251,173)
Inventories	56,122	1,267	(21,451)
Prepaid expenses and other current assets	(79,245)	(88,193)	(114,788)
Accounts payable	122,232	(12,197)	16,015
Accrued trade discounts and rebates	2,399	(36,929)	(113,991)
Accrued expenses and other current liabilities	(59,101)	50,622	114,621
Other non-current assets and liabilities	(10,930)	(11,106)	25,092
Net cash provided by operating activities	1,257,842	1,035,271	555,688
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(64,026)	(76,596)	(169,852)
Payments related to license and collaboration agreements	(62,250)	(51,572)	(30,000)
Payments for long-term investments	(9,236)	(28,256)	(14,108)
Payments for acquisitions, net of cash acquired	(3,122)	(2,843,275)	(262,305)
Proceeds from sale of assets		2,000	5,400
Change in escrow deposit for property purchase			6,000
Receipts from long-term investments	4,633	3,588	794
Net cash used in investing activities	(134,001)	(2,994,111)	(464,071)
CASH FLOWS FROM FINANCING ACTIVITIES:
Repurchase of ordinary shares	(250,078)
Payment of employee withholding taxes relating to share-based awards	(137,247)	(165,964)	(66,505)
Repayment of term loans	(16,000)	(12,000)
Net proceeds from term loans		1,574,993
Repayment of senior notes			(1,739)
Net proceeds from the issuance of ordinary shares			919,786
Proceeds from the issuance of ordinary shares in conjunction with Employee Share Purchase Plan	25,051	22,528	16,168
Proceeds from the issuance of ordinary shares in connection with stock option exercises	30,316	50,566	36,869
Net cash provided by (used in) financing activities	(347,958)	1,470,123	904,579
Effect of foreign exchange rate changes on cash, cash equivalents and restricted cash	(2,451)	(10,606)	7,244
Net increase (decrease) in cash, cash equivalents and restricted cash	773,432	(499,323)	1,003,440
Cash, cash equivalents and restricted cash, beginning of the year	1,584,156	2,083,479	1,080,039
Cash, cash equivalents and restricted cash, end of the year	2,357,588	1,584,156	2,083,479
SUPPLEMENTAL CASH FLOW INFORMATION:
Cash paid for interest	106,480	74,353	51,863
Cash paid for income taxes, net of refunds received	19,845	97,235	15,115
Cash paid for amounts included in the measurement of operating lease liabilities	8,343	8,868	7,840
SUPPLEMENTAL NON-CASH FLOW INFORMATION:
Lease liabilities arising from obtaining right-of-use assets	30,763	62,156
Purchases of property, plant and equipment included in accounts payable and accrued expenses and other current liabilities	17,032	9,228	13,430
Purchases of acquired in-process research and development and milestones included in accrued expenses and other current liabilities	$ 15,000	$ 25,000
Principal amount of 2.5% Exchangeable Senior Notes due 2022 converted into ordinary shares			398,261
Milestone payments for TEPEZZA intangible asset included in accrued expenses and other current liabilities			$ 123,442