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Consolidated Statements of Comprehensive Income - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Statement [Abstract]      
Net sales $ 3,629,044 $ 3,226,410 $ 2,200,429
Cost of goods sold 920,197 794,512 532,695
Gross profit 2,708,847 2,431,898 1,667,734
OPERATING EXPENSES:      
Research and development 437,962 345,318 128,999
Acquired in-process research and development and milestones 56,250 86,672 80,365
Selling, general and administrative 1,541,052 1,446,410 973,227
Impairment of goodwill 56,171    
Impairment of long-lived asset   12,371  
Gain on sale of assets   (2,000) (4,883)
Total operating expenses 2,091,435 1,888,771 1,177,708
Operating income 617,412 543,127 490,026
OTHER EXPENSE, NET:      
Interest expense, net (83,707) (81,063) (59,616)
Foreign exchange loss (1,202) (1,028) (297)
Loss on debt extinguishment     (31,856)
Other (expense) income, net (5,567) 1,791 3,388
Total other expense, net (90,476) (80,300) (88,381)
Income before expense (benefit) for income taxes 526,936 462,827 401,645
Expense (benefit) for income taxes 5,454 (71,664) 11,849
Net income $ 521,482 $ 534,491 $ 389,796
Net income per ordinary share—basic $ 2.28 $ 2.37 $ 1.91
Weighted average ordinary shares outstanding—basic 229,108,881 225,551,410 203,967,246
Net income per ordinary share—diluted $ 2.22 $ 2.27 $ 1.81
Weighted average ordinary shares outstanding—diluted 235,239,651 235,680,483 215,308,768
OTHER COMPREHENSIVE INCOME (LOSS), NET OF TAX      
Interest rate swap contracts designated as cash flow hedges $ 23,640    
Pension and other post-employment benefit plan remeasurements 4,671 $ (13,296)  
Foreign currency translation adjustments (796) (1,546) $ 1,760
Other comprehensive income (loss) 27,515 (14,842) 1,760
Comprehensive income $ 548,997 $ 519,649 $ 391,556