X0508 4 2025-07-14 0001492422 Apellis Pharmaceuticals, Inc. APLS 0001658080 Francois Cedric C/O APELLIS PHARMACEUTICALS, INC. 100 FIFTH AVENUE, 3RD FLOOR WALTHAM MA 02451 1 1 Chief Executive Officer 1 Common Stock 2025-07-14 4 M 0 65203 4.31 A 480898 D Common Stock 2025-07-14 4 S 0 137465 20.1864 D 343433 D Common Stock 2025-07-15 4 M 0 800 4.31 A 344233 D Common Stock 2025-07-15 4 S 0 1900 20.0884 D 342333 D Common Stock 532946 I Indirect Owner (The Cedric Francois Irrevocable Trust of 2023 - 2) Common Stock 472065 I Indirect Owner (The Cedric Francois Irrevocable Trust of 2023) Common Stock 300000 I Indirect Owner (The Francois Grossi Trust) Common Stock 234411 I Indirect Owner (The Francois-DuBois Educational Trust) Stock Option (Right to Buy) 4.31 2025-07-14 4 M 0 65203 0 D 2027-08-20 Common Stock 65203 110335 D Stock Option (Right to Buy) 4.31 2025-07-15 4 M 0 800 0 D 2027-08-20 Common Stock 800 109535 D This is a scheduled exercise & sale from 10b5-1 trading plan dated March 10, 2025. This transaction was executed in multiple trades at prices ranging from $20 - $20.58. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected. This transaction was executed in multiple trades at prices ranging from $20 - $20.19. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected. The securities are held by The Cedric Francois Irrevocable Trust of 2023 - 2. William V. A. Zorn is the trustee of The Cedric Francois Irrevocable Trust of 2023 - 2. The reporting person disclaims beneficial ownership over the shares held by The Cedric Francois Irrevocable Trust of 2023 - 2 except to the extent of his pecuniary interest therein. The securities are held by The Cedric Francois Irrevocable Trust of 2023. William V. A. Zorn is the trustee of The Cedric Francois Irrevocable Trust of 2023. The reporting person disclaims beneficial ownership over the shares held by The Cedric Francois Irrevocable Trust of 2023 except to the extent of his pecuniary interest therein. The securities are held by The Francois Grossi Trust, for which Juliana Grossi, the spouse of the reporting person, serves as trustee. The reporting person disclaims beneficial ownership over the shares held by the Francois Grossi Trust except to the extent of his pecuniary interest therein. The securities are held by The Francois-DuBois Educational Trust, for which the Fiduciary Trust Company of New England serves as trustee. The reporting person disclaims beneficial ownership over the shares held by The Francois-DuBois Educational Trust except to the extent of his pecuniary interest therein. This option was granted on August 21, 2017 and is fully vested. /s/ David Watson, attorney-in-fact for Cedric Francois 2025-07-16