X0508 4 2025-01-13 0001492422 Apellis Pharmaceuticals, Inc. APLS 0001814304 Lewis Karen C/O APELLIS PHARMACEUTICALS, INC. 100 FIFTH AVENUE, 3RD FLOOR WALTHAM MA 02451 1 Chief People Officer 0 Common Stock 2025-01-13 4 S 0 1599 28.7021 D 45099 D This represents shares sold to cover tax withholding on the Restricted Stock Units released on January 10, 2025. This includes 116 shares from April 30, 2024 ESPP purchase and 195 shares from the October 31, 2024 ESPP purchase. /s/ David Watson, attorney-in-fact for Karen Lewis 2025-01-14