X0508 4 2024-06-28 0001492422 Apellis Pharmaceuticals, Inc. APLS 0001721108 Dunlop A. Sinclair C/O APELLIS PHARMACEUTICALS, INC. 100 FIFTH AVENUE, 3RD FLOOR WALTHAM MA 02451 1 0 Common Stock 2024-06-28 4 M 0 900 13.19 A 134418 D Common Stock 136998 I Indirect Owner (Epidarex) Common Stock 31855 I Indirect Owner (Masa) Stock Option (Right to Buy) 13.19 2024-06-28 4 M 0 900 0 D 2028-12-31 Common Stock 900 4600 D The securities are held by Epidarex and the reporting person, a general partner of Epidarex, may be deemed to have voting and dispositive power over the shares held by Epidarex. The reporting person disclaims beneficial ownership over the shares held by Epidarex except to the extent of his pecuniary interest therein. The securities are held by MASA and the reporting person, a managing partner of MASA, may be deemed to have voting and dispositive power over the shares held by MASA. The reporting person disclaims beneficial ownership over the shares held by MASA except to the extent of his pecuniary interest therein. This option was granted on January 1, 2019 and fully vested. /s/ David Watson, attorney-in-fact for Sinclair Dunlop 2024-07-01