X0306 4 2023-01-12 0001492422 Apellis Pharmaceuticals, Inc. APLS 0001657719 Watson David O. C/O APELLIS PHARMACEUTICALS, INC WALTHAM MA 02451 1 General Counsel Common Stock 2023-01-12 4 A 0 24003 0 A 139572 D Common Stock 2023-01-12 4 A 0 29452 0 A 169024 D Common Stock 3333 I Indirect Owner (Custodial Account for Son) Common Stock 6667 I Indirect Owner (The Watson Education Trust) Stock Option (Right to Buy) 52.66 2023-01-12 4 A 0 37708 52.66 A 2033-01-11 Common Stock 37708 37708 D This represents a Restricted Stock Unit award granted 01/12/23 that vest annually from grant date over a four year period subject to continued service. This represents a Restricted Stock Unit award granted 01/12/23 that vest annually from grant date over a four year period subject to continued service. This represents a custodial account held by the reporting person for the sole benefit of his minor son. The securities are held by The Watson Education Trust (the "Trust"), for which the reporting person serves as trustee. The reporting person disclaims beneficial ownership over the shares held by the Trust except to the extent of his pecuniary interest therein. This represents a stock option award granted 01/12/2023 that vest over a four year period. 25% vest one year from grant date and the remaining 75% vest monthly thereafter subject to continued service. David Watson 2023-01-17