X0306 4 2022-04-21 0001492422 Apellis Pharmaceuticals, Inc. APLS 0001657719 Watson David O. C/O APELLIS PHARMACEUTICALS, INC 100 FIFTH AVENUE, 3RD FLOOR WALTHAM MA 02451 1 General Counsel Common Stock 2022-04-21 4 J 0 1875 0 D 130569 D Common Stock 2022-04-25 4 S 0 5000 50.00 D 125569 D Common Stock 3333 I Indirect Owner (Custodial Account for Son) Common Stock 6667 I Indirect Owner (The Watson Education Trust) Stock Option (Right to Buy) 44.90 2022-04-21 4 J 0 11250 0 D 2031-01-27 Common Stock 11250 0 D This represents the cancellation of a PSU awards granted on 01/28/2021 that was originally reported in table I upon grant. The performance metrics were not met. This is a scheduled sale from an established 10B5-1 trading plan. This represents a custodial account held by the reporting person for the sole benefit of his minor son. The securities are held by The Watson Education Trust (the "Trust"), for which the reporting person serves as trustee. The reporting person disclaims beneficial ownership over the shares held by the Trust except to the extent of his pecuniary interest therein. This represents the cancellation of a performance stock option granted on 01/28/01. The performance metrics were not met. This stock option will vest as to 25% of the shares underlying the options on the first anniversary of the grant, with the remaining 75% of the shares underlying the options vesting in equal monthly installments thereafter through the fourth anniversary of the grant, subject to the satisfaction of a specified performance condition and continued service. /s/ David Watson 2022-04-26