X0306 4 2022-02-10 0001492422 Apellis Pharmaceuticals, Inc. APLS 0001658080 Francois Cedric C/O APELLIS PHARMACEUTICALS, INC. 100 FIFTH AVENUE, 3RD FLOOR WALTHAM MA 02451 1 1 Chief Executive Officer Common Stock 2022-02-10 4 F 0 2523 47.12 D 955940 D Common Stock 300000 I The Francois Grossi Trust Common Stock 234411 I The Francois-DuBois Educational Trust This represents shares used to cover tax withholding on a Restricted Stock Unit release. The securities are held by The Francois Grossi Trust, for which Juliana Grossi, the spouse of the reporting person, serves as trustee. The reporting person disclaims beneficial ownership over the shares held by the Francois Grossi Trust except to the extent of his pecuniary interest therein. The securities are held by The Francois-DuBois Educational Trust, for which the Fiduciary Trust Company of New England serves as trustee. The reporting person disclaims beneficial ownership over the shares held by The Francois-DuBois Educational Trust except to the extent of his pecuniary interest therein. /s/David Watson, attorney-in-fact for Cedric Francois 2022-02-14