X0306 4 2021-06-21 0001492422 Apellis Pharmaceuticals, Inc. APLS 0001657719 Watson David O. C/O APELLIS PHARMACEUTICALS, INC 100 FIFTH AVENUE, 3RD FLOOR WALTHAM MA 02451 1 General Counsel Common Stock 2021-06-21 4 M 0 489 4.31 A 98239 D Common Stock 10000 I See Footnote Stock Option (Right to Buy) 4.31 2021-06-21 4 M 0 489 0 D 2027-08-20 Common Stock 489 954 D The securities are held by The Watson Education Trust (the "Trust"), for which the reporting person serves as trustee. The reporting person disclaims beneficial ownership over the shares held by the Trust except to the extent of his pecuniary interest therein. This stock option will vest as to 25% of the shares underlying the options on the first anniversary of the grant, with the remaining 75% of the shares underlying the options vesting in equal monthly installments thereafter through the fourth anniversary of the grant, subject to continued service. /s/ David Watson 2021-06-22