Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating Activities
Net loss	$ (294,912)	$ (402,850)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	43,303	34,161
Loss on conversion of debt		39,487
Loss from remeasurement of development derivative liability		38,264
Forfeiture of accrued interest in exchange of convertible notes		1,668
Amortization of right-of-use assets	(61)	118
Depreciation expense	763	724
Amortization of discounts for convertible notes, net of financing costs	290	679
Accretion of discount to development liability	13,336
Other liabilities	1,571
Changes in operating assets and liabilities:
Accounts receivable	2,584	(719)
Inventory	(32,134)	(3,731)
Prepaid assets	3,390	(7,473)
Other current assets	42,225	(4,311)
Other assets	15,757	2,758
Accounts payable	2,591	(3,296)
Accrued expenses	(17,287)	22,519
Net cash used in operating activities	(218,584)	(282,002)
Investing Activities
Purchase of property and equipment	(477)	(732)
Purchase of available-for-sale securities	(331,863)	(171,281)
Proceeds from maturity of available-for-sale securities	143,320	155,000
Net cash used in investing activities	(189,020)	(17,013)
Financing Activities
Proceeds from issuance of common stock, net of issuance costs	380,120
Payments for development derivative liability		(4,000)
Payments for development liability	(16,500)
Proceeds from exercise of stock options	8,770	9,650
Proceeds from issuance of common stock under employee share purchase plan	2,531	1,698
Payments of employee tax withholding related to equity-based compensation	(2,952)	(1,190)
Net cash provided by financing activities	371,969	6,158
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(365)	(1,852)
Net decrease in cash, cash equivalents and restricted cash	(36,000)	(294,709)
Cash, cash equivalents and restricted cash at beginning of period	641,755	567,045
Cash, cash equivalents and restricted cash at end of period	605,755	272,336
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets:
Cash and cash equivalents	604,489	270,764
Restricted cash	1,266	1,572
Total cash, cash equivalents, and restricted cash	605,755	272,336
Supplemental Disclosure of Financing Activities
Cash paid for interest	3,360	6,893
Cash paid for income taxes	$ 156
Convertible Notes exchanged for common stock		$ 126,129