X0306 4 2023-01-01 0 0001492422 Apellis Pharmaceuticals, Inc. APLS 0001496687 Machiels Alec C/O APELLIS PHARMACEUTICALS, INC. 100 FIFTH AVENUE. WALTHAM MA 02451 1 0 0 0 Common Stock 2023-01-01 4 A 0 3867 0.00 A 267641 D Common Stock 250000 I Indirect Owner (Bauhaus 1 LLC) Common Stock 11950 I Indirect Owner (Owned by Spouse) Common Stock 150000 I Indirect Owner (Spouse Trust) Stock Option (Right to Buy) 51.71 2023-01-01 4 A 0 7441 0.00 A 2030-12-31 Common Stock 7441 7441 D This restricted stock unit was granted on January 1, 2023. The restricted stock unit will fully vest on the first anniversary of the date of grant, subject to his continued service as a director, or upon later termination of his service as a director at his election. The shares are held by Bauhaus 1 LLC, which LLC is held by The Irrevocable Agreement of Trust of Alec Machiels (the "Trust"). The reporting person is the managing member of Bauhaus 1 LLC and the trustee of the Trust. The shares are owned by the reporting person's spouse. On September 7, 2021, the reporting person's spouse transferred 150,000 shares of Apellis Pharmaceuticals, Inc. common stock to her trust, of which the reporting person is the trustee. This option was granted on January 1, 2023. The option vests quarterly on the last day of each quarter from the date of grant, subject to his continued service as a director and expires seven years after the date of grant. /s/ David Watson, attorney-in-fact for Alec Machiels 2023-01-04