X0101 EFFECT 33 LIVE 2010-12-30 14:45:00

N-1A

0001492374 Destra Investment Trust 333-167073 S000029616 Destra Global Liquidity All-Cap Fund C000090934 Class A S000029616 Destra Global Liquidity All-Cap Fund C000090935 Class C S000029616 Destra Global Liquidity All-Cap Fund C000090936 Class P S000029616 Destra Global Liquidity All-Cap Fund C000090937 Class I S000029617 Destra International Liquidity All-Cap Fund C000090938 Class A S000029617 Destra International Liquidity All-Cap Fund C000090939 Class C S000029617 Destra International Liquidity All-Cap Fund C000090940 Class P S000029617 Destra International Liquidity All-Cap Fund C000090941 Class I S000029618 Destra U.S. Liquidity All-Cap Fund C000090942 Class C S000029618 Destra U.S. Liquidity All-Cap Fund C000090943 Class P S000029618 Destra U.S. Liquidity All-Cap Fund C000090944 Class I S000029618 Destra U.S. Liquidity All-Cap Fund C000090945 Class A