Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues
Revenue	$ 64,399	$ 142,766	$ 171,349	$ 175,303
Expenses:
Cost of sales - product	$ 14,225	$ 6,216	$ 37,735	$ 10,280
Type of Reveune	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Cost of sales - intangible asset amortization	$ 728	$ 1,254	$ 3,663	$ 4,723
Research and development	94,188	73,388	288,551	210,910
Selling, general and administrative	93,497	83,998	287,137	246,239
Acquired in-process research and development				7,000
Total expenses	202,638	164,856	617,086	479,152
Loss from operations	(138,239)	(22,090)	(445,737)	(303,849)
Interest expense	(18,179)	(4,424)	(43,101)	(13,117)
Interest income	1,944	1,133	5,143	2,933
Gain on sale of business	17,627		17,627
Other income	81	243	243	243
Loss before income taxes	(136,766)	(25,138)	(465,825)	(313,790)
Provision for (benefit from) income taxes	322	139	730	271
Net loss	$ (137,088)	$ (25,277)	$ (466,555)	$ (314,061)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (2.49)	$ (0.47)	$ (8.51)	$ (5.82)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	54,957	54,241	54,807	53,971
Comprehensive income (loss):
Net loss	$ (137,088)	$ (25,277)	$ (466,555)	$ (314,061)
Other comprehensive income (loss):
Unrealized gain on pension obligation	(62)	(46)	(186)	(137)
Foreign currency translation adjustments	(406)	131	(2,543)	421
Other comprehensive income (loss)	(344)	177	(2,357)	558
Comprehensive income (loss)	(137,432)	(25,100)	(468,912)	(313,503)
Product revenue
Revenues
Revenue	63,612	41,755	170,312	72,723
Licenses, collaboration and other revenues
Revenues
Revenue	$ 787	$ 101,011	$ 1,037	$ 102,580