Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues
Revenue	$ 57,208	$ 29,464	$ 106,950	$ 32,537
Expenses:
Cost of sales - product	13,513	3,620	$ 23,510	$ 4,064
Type of Cost, Good or Service [Extensible List]			Product [Member]	Product [Member]
Cost of sales - intangible asset amortization	1,498	2,979	$ 2,935	$ 3,469
Research and development	97,608	71,400	194,363	137,522
Selling, general and administrative	100,033	92,979	193,640	162,241
Acquired in-process research and development		7,000		7,000
Total expenses	212,652	177,978	414,448	314,296
Loss from operations	(155,444)	(148,514)	(307,498)	(281,759)
Interest expense	(12,830)	(4,426)	(24,922)	(8,693)
Interest income	1,534	959	3,199	1,800
Other income	81		162
Loss before income taxes	(166,659)	(151,981)	(329,059)	(288,652)
Provision for (benefit from) income taxes	(8)	78	408	132
Net loss	$ (166,651)	$ (152,059)	$ (329,467)	$ (288,784)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (3.04)	$ (2.82)	$ (6.02)	$ (5.36)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	54,845	53,982	54,731	53,834
Comprehensive income (loss):
Net loss	$ (166,651)	$ (152,059)	$ (329,467)	$ (288,784)
Other comprehensive income(loss):
Unrealized gain on pension obligation	(61)	(46)	(124)	(91)
Foreign currency translation adjustments	(2,598)	255	(2,137)	290
Other comprehensive income (loss)	(2,537)	301	(2,013)	381
Comprehensive income (loss)	(169,188)	(151,758)	(331,480)	(288,403)
Product revenue
Revenues
Revenue	56,528	28,829	106,700	30,968
Licenses, collaboration and other revenues
Revenues
Revenue	$ 680	$ 635	$ 250	$ 1,569