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License and Collaboration Agreements - Janssen Biotech Inc (Details) - USD ($)
$ in Thousands
3 Months Ended
Apr. 05, 2017
Apr. 05, 2016
Mar. 31, 2018
Mar. 31, 2017
License Agreements        
Transaction price recognized     $ 49,742 $ 3,073
Janssen Biotech, Inc.        
License Agreements        
Up-front payment received   $ 35,000    
Period over which performance obligation will be recognized as revenue     36 months  
Collaborative Arrangement | Janssen Biotech, Inc.        
License Agreements        
Prior written notice to terminate programs 90 days      
Changes occurred in the transaction price of previously delivered goods     $ 0  
Collaborative Arrangement | Maximum | Janssen Biotech, Inc.        
License Agreements        
Period of time to provide electronic copies of know-how relating to development of product   30 days    
Collaborative Arrangement | Maximum | Achievement of clinical milestones | Janssen Biotech, Inc.        
License Agreements        
Potential milestone payments   $ 43,000    
Collaborative Arrangement | Maximum | Achievement of regulatory and sales milestones | Janssen Biotech, Inc.        
License Agreements        
Potential milestone payments   $ 372,000    
Joint Committee performance obligation arrangement | Janssen Biotech, Inc.        
License Agreements        
Transaction price recognized     $ 500  
Period over which performance obligation will be recognized as revenue     5 years  
Transaction price     $ 300  
Licenses, collaboration and other revenues        
License Agreements        
Transaction price recognized       934
Manufacturing supply services | Collaborative Arrangement | Janssen Biotech, Inc.        
License Agreements        
Other revenue     $ 500 $ 900