Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Net product revenue
Revenue	$ 49,742	$ 3,073
Reversal of license revenue	(1,000)
Expenses:
Cost of sales - product	9,997	444
Cost of sales - intangible asset amortization	1,437	490
Research and development	96,755	66,122
Selling, general and administrative	93,607	69,262
Total expenses	201,796	136,318
Loss from operations	(152,054)	(133,245)
Interest expense	(12,092)	(4,267)
Interest income	1,665	841
Other income	81
Loss before income taxes	(162,400)	(136,671)
Provision for income taxes	416	54
Net loss	$ (162,816)	$ (136,725)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (2.98)	$ (2.55)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	54,615	53,685
Comprehensive income:
Net loss	$ (162,816)	$ (136,725)
Other comprehensive income:
Unrealized gain/(loss) on pension obligation	(63)	(45)
Foreign currency translation adjustments	462	35
Other comprehensive income:	525	80
Comprehensive loss	(162,291)	(136,645)
Product revenue
Net product revenue
Revenue	50,172	2,139
Licenses, collaboration and other revenues
Net product revenue
Revenue		$ 934
Reversal of license revenue	$ (430)