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Revenue Recognition - performance of obligations (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Performance of obligations        
Amounts included in the contract liability in the beginning of the period     $ 70 $ 45
Out-licensing agreements        
Performance of obligations        
Amounts included in the contract liability in the beginning of the period $ 23 $ 15