Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Product revenue, net	$ 41,755	$ 1,326	$ 72,723	$ 2,844
License revenue	101,011	15,661	102,580	50,253
Total revenues	142,766	16,987	175,303	53,097
Expenses:
Cost of sales - product	6,216	378	10,280	691
Cost of sales - intangible asset amortization	1,254	464	4,723	1,391
Research and development	73,388	60,783	210,910	163,630
Selling, general and administrative	83,998	37,685	246,239	104,052
Acquired in-process research and development		1,940	7,000	9,940
Total expenses	164,856	101,250	479,152	279,704
Loss from operations	(22,090)	(84,263)	(303,849)	(226,607)
Interest expense	(4,424)	(4,119)	(13,117)	(12,220)
Interest income	1,133	532	2,933	843
Other income	243		243
Loss before income taxes	(25,138)	(87,850)	(313,790)	(237,984)
Provision for income taxes	139		271
Net loss	$ (25,277)	$ (87,850)	$ (314,061)	$ (237,984)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (0.47)	$ (1.72)	$ (5.82)	$ (5.17)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	54,241	51,151	53,971	45,994
Comprehensive loss:
Net loss	$ (25,277)	$ (87,850)	$ (314,061)	$ (237,984)
Other comprehensive income (loss):
Unrealized gain/(loss) on pension obligation	(46)	(1)	(137)	98
Foreign currency translation adjustments	131		421
Other comprehensive income/(loss)	177	1	558	(98)
Comprehensive loss	$ (25,100)	$ (87,849)	$ (313,503)	$ (238,082)