Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2017	Dec. 31, 2016
Accrued Expenses
Research and development	$ 40,460	$ 36,759
Salaries, bonuses and other compensation	29,699	20,654
Accrued inventory	27,032
Accrued royalty	4,116	2,059
Accrued other	21,769	9,228
Total accrued expenses	$ 123,076	$ 68,700