Intangible Assets (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2016
Intangible Assets
Intangible asset - OPKO milestone	$ 50,000		$ 50,000		$ 15,000
Less: accumulated amortization	(5,592)		(5,592)		(2,123)
Total intangible asset, net	44,408		44,408		$ 12,877
Amortization expense	3,000	$ 500	3,500	$ 900
Estimated future amortization expense
2017	2,500		2,500
2018	5,000		5,000
2019	5,000		5,000
2020	5,000		5,000
2021	5,000		5,000
Thereafter	$ 21,800		$ 21,800
Use Rights [Member] | Minimum
Intangible Assets
Estimated useful life			8 years
Use Rights [Member] | Maximum
Intangible Assets
Estimated useful life			13 years
OPKO Health Inc | Achievement Of First Commercial Sale Of VARUBY In Europe
Intangible Assets
Additional milestone payment			$ 10,000
Merck Sharp & Dohme B.V. | Achievement Of FDA Approval Of ZEJULA
Intangible Assets
Additional milestone payment			$ 25,000