Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
Product revenue, net	$ 28,829	$ 1,242	$ 30,968	$ 1,518
License revenue	635	34,568	1,569	34,592
Total revenues	29,464	35,810	32,537	36,110
Expenses:
Cost of sales - product	3,620	234	4,064	313
Cost of sales - intangible asset amortization	2,979	463	3,469	927
Research and development	71,400	50,138	137,522	102,847
Selling, general and administrative	92,979	36,218	162,241	66,367
Acquired in-process research and development	7,000	4,000	7,000	8,000
Total expenses	177,978	91,053	314,296	178,454
Loss from operations	(148,514)	(55,243)	(281,759)	(142,344)
Interest expense	(4,426)	(4,120)	(8,693)	(8,101)
Interest income	959	209	1,800	311
(Loss) income before provision for -benefit from income taxes	(151,981)	(59,154)	(288,652)	(150,134)
Income Tax Expense (Benefit)	78		132
Net loss	$ (152,059)	$ (59,154)	$ (288,784)	$ (150,134)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (2.82)	$ (1.29)	$ (5.36)	$ (3.46)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	53,982	45,808	53,834	43,387
Comprehensive loss:
Net loss	$ (152,059)	$ (59,154)	$ (288,784)	$ (150,134)
Other comprehensive income (loss):
Unrealized gain/(loss) on pension obligation	(46)	(1)	(91)	98
Foreign currency translation adjustments	255		290
Other comprehensive income/(loss)	301	1	381	(98)
Comprehensive loss	$ (151,758)	$ (59,153)	$ (288,403)	$ (150,232)