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License and Collaboration Arrangements (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Sep. 30, 2016
Sep. 28, 2016
item
Apr. 05, 2016
USD ($)
Jul. 31, 2015
USD ($)
item
Mar. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Sep. 30, 2016
USD ($)
Jun. 30, 2016
USD ($)
Mar. 31, 2016
USD ($)
Sep. 30, 2015
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
License Agreements                          
License revenue         $ 15,700             $ 15,700  
Research and development expense         66,122       $ 52,709        
Zai Lab (Shanghai) Co., Ltd.                          
License Agreements                          
Proceeds from License Fees Received           $ 15,000              
Jiangsu Hengrui Medicine Co., Ltd.                          
License Agreements                          
Upfront payment received       $ 1,000                  
Proceeds from License Fees Received       $ 1,000                  
Number of novel, discovery-stage immuno-oncology programs for which the Company has option to negotiate licenses | item       2                  
License revenue       $ 1,000                  
Additional milestone payment       $ 1,000                  
Up-front payment arrangement                          
License Agreements                          
Deferred Revenue         376 $ 399     77   $ 376 399 $ 92
Deferred Revenue, Revenue Recognized         23       15        
Up-front payment arrangement | Janssen                          
License Agreements                          
Upfront payment received     $ 35,000                    
Research Agreement | Merck                          
License Agreements                          
Research and development expense         2,100       800        
Cost-sharing receivable         1,000       $ 400        
Research Agreement | Other current assets | Merck                          
License Agreements                          
Cost-sharing receivable         1,100                
Collaborative Arrangement                          
License Agreements                          
License revenue             $ 200            
Transaction price             $ 14,800            
Milestone payments required, if certain research and development milestone events are achieved         2,700           2,700    
Collaborative Arrangement | Janssen                          
License Agreements                          
Upfront payment received               $ 35,000          
Threshold period within which transaction price is recognized as revenue after entering into collaboration agreement               30 days          
Collaborative Arrangement | Zai Lab (Shanghai) Co., Ltd.                          
License Agreements                          
Expiration period of collaborative arrangement 10 years                        
Number of clinical or regulatory milestones included in transaction price | item   2                      
Collaborative Arrangement | Achievement of clinical milestones | Janssen                          
License Agreements                          
Potential milestone payments     43,000                    
Collaborative Arrangement | Achievement of regulatory and sales milestones | Janssen                          
License Agreements                          
Potential milestone payments     372,000                    
Collaborative Arrangement | Achievement of clinical, regulatory and sales milestones | Janssen                          
License Agreements                          
Potential milestone payments     $ 0                    
Collaborative Arrangement | Minimum | Janssen                          
License Agreements                          
Termination period     90 days                    
Collaborative Arrangement | Maximum | Janssen                          
License Agreements                          
Period of time to provide electronic copies of know-how relating to development of product     30 days                    
Collaborative Arrangement | License arrangement | Janssen                          
License Agreements                          
Amount of deferred revenue allocated to arrangement               $ 34,500          
Collaborative Arrangement | Joint Committee performance obligation arrangement | Janssen                          
License Agreements                          
License revenue                     34,600    
Period for recognizing performance obligation               5 years          
Amount of deferred revenue allocated to arrangement               $ 500          
Deferred Revenue         $ 400           $ 400    
Period by which transaction price will be recognized as revenue         48 months                
License Agreement                          
License Agreements                          
License revenue         $ 2,000             $ 2,000  
Transaction price                   $ 1,900      
Milestone payments required, if certain research and development milestone events are achieved                   $ 100