Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Product revenue, net	$ 2,139	$ 276
License, collaboration and other revenues	934	24
Total revenues	3,073	300
Expenses:
Cost of sales - product	444	79
Cost of sales - intangible asset amortization	490	464
Research and development	66,122	52,709
Selling, general and administrative	69,262	30,149
Acquired in-process research and development		4,000
Total expenses	136,318	87,401
Loss from operations	(133,245)	(87,101)
Interest expense	(4,267)	(3,981)
Interest income	841	102
Loss before income taxes	(136,671)	(90,980)
Provision for income taxes	54
Net loss	$ (136,725)	$ (90,980)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (2.55)	$ (2.22)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	53,685	40,966
Comprehensive loss:
Net loss	$ (136,725)	$ (90,980)
Other comprehensive gain (loss):
Unrealized gain (loss) on pension obligation	45	(99)
Foreign currency translation adjustments	35
Other comprehensive gain (loss):	80	(99)
Comprehensive loss	$ (136,645)	$ (91,079)