Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Current assets:
Cash and cash equivalents	$ 672,239	$ 785,877
Accounts receivable	6,061	6,195
Inventories	15,643	14,700
Other current assets	13,625	10,515
Total current assets	707,568	817,287
Intangible assets, net	37,387	12,877
Property and equipment, net	8,618	6,640
Restricted cash	2,316	1,694
Other assets	5,116	3,795
Total assets	761,005	842,293
Current liabilities:
Accounts payable	10,343	5,236
Accrued expenses	68,975	68,700
Accrued milestone obligation	24,790
Deferred revenue, current	95	95
Other current liabilities	3,264	2,978
Total current liabilities	107,467	77,009
Convertible notes, net	134,532	131,775
Deferred revenue, non-current	282	305
Other non-current liabilities	5,516	5,086
Total liabilities	247,797	214,175
Commitments and contingencies (Notes 10 and 12)
Stockholders' equity:
Preferred stock, $0.0001 par value; 10,000,000 shares authorized at both December 31, 2016 and March 31, 2017; no shares issued or outstanding at both December 31, 2016 and March 31, 2017
Common stock, $0.0001 par value; 100,000,000 shares authorized at both December 31, 2016 and March 31, 2017; 53,621,679 and 53,815,936 shares issued and outstanding at December 31, 2016 and March 31, 2017, respectively	5	5
Additional paid-in capital	1,626,533	1,604,798
Accumulated other comprehensive loss	(2,844)	(2,924)
Accumulated deficit	(1,110,486)	(973,761)
Total stockholders' equity	513,208	628,118
Total liabilities and stockholders' equity	$ 761,005	$ 842,293