Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues:
Product revenue, net	$ 6,877	$ 0	$ 0
License revenue	37,946	317
Total revenues	44,823	317
Expenses:
Cost of sales - product	1,256
Cost of sales - intangible asset amortization	1,855	268
Research and development	235,144	155,390	118,425
Selling, general and administrative	158,578	78,701	23,935
Acquired in-process research and development	18,940	2,000	24,900
Total expenses	415,773	236,359	167,260
Loss from operations	(370,950)	(236,042)	(167,260)
Interest expense	(16,487)	(15,414)	(3,776)
Interest income	1,440	48	24
(Loss) income before provision for -benefit from income taxes	(385,997)	(251,408)	(171,012)
Income Tax Expense (Benefit)	1,475
Net loss	$ (387,472)	$ (251,408)	$ (171,012)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (8.13)	$ (6.38)	$ (4.79)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	47,652	39,387	35,739
Comprehensive loss:
Net loss	$ (387,472)	$ (251,408)	$ (171,012)
Other comprehensive income/(loss):
Unrealized gain/(loss) on pension obligation	(2,782)
Foreign currency translation adjustments	(142)
Other comprehensive income/(loss)	(2,924)
Comprehensive loss	$ (390,396)	$ (251,408)	$ (171,012)