Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues:
Product revenue, net	$ 2,799	$ 0	$ 4,408	$ 0
License revenue	931	87	36,190	87
Total revenues	3,730	87	40,598	87
Expenses:
Cost of sales - product	424		738
Cost of sales - intangible asset amortization	464		1,391
Research and development	60,783	40,063	163,630	112,538
Selling, general and administrative	37,685	22,766	104,052	50,791
Acquired in-process research and development	1,940		9,940	1,000
Total expenses	101,296	62,829	279,751	164,329
Loss from operations	(97,566)	(62,742)	(239,153)	(164,242)
Interest expense	(4,119)	(3,853)	(12,220)	(11,432)
Interest income	532	9	843	25
Net loss	$ (101,153)	$ (66,586)	$ (250,530)	$ (175,649)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (1.98)	$ (1.66)	$ (5.45)	$ (4.49)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	51,151	40,038	45,994	39,129
Comprehensive loss:
Net loss	$ (101,153)	$ (66,586)	$ (250,530)	$ (175,649)
Other comprehensive income/(loss):
Unrealized gain/(loss) on pension obligation			(98)
Other comprehensive income/(loss)			(98)
Comprehensive loss	$ (101,153)	$ (66,586)	$ (250,628)	$ (175,649)