Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenues:
Product revenue, net	$ 1,436		$ 1,609	$ 0
License revenue	35,125		35,259
Total revenues	36,561		36,868
Expenses:
Cost of sales - product	238		314
Cost of sales - intangible asset amortization	463		927
Research and development	50,138	$ 38,930	102,847	72,475
Selling, general and administrative	36,218	16,783	66,367	28,025
Acquired in-process research and development	4,000	1,000	8,000	1,000
Total expenses	91,057	56,713	178,455	101,500
Loss from operations	(54,496)	(56,713)	(141,587)	(101,500)
Interest expense	(4,120)	(3,853)	(8,101)	(7,579)
Interest income	209	9	311	16
Net loss	$ (58,407)	$ (60,557)	$ (149,377)	$ (109,063)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (1.28)	$ (1.51)	$ (3.44)	$ (2.82)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	45,808	40,008	43,387	38,667
Comprehensive loss:
Net loss	$ (58,407)	$ (60,557)	$ (149,377)	$ (109,063)
Other comprehensive income/(loss):
Unrealized gain/(loss) on pension obligation	1		(98)
Other comprehensive income/(loss)	1		(98)
Comprehensive loss	$ (58,406)	$ (60,557)	$ (149,475)	$ (109,063)