Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenue
Product revenue, net	$ 173	$ 0
License revenue	134
Total revenues	307
Expenses:
Cost of sales - product	76
Cost of sales - intangible asset amortization	464
Research and development	52,632	33,545
Selling, general and administrative	30,023	11,242
Acquired in-process research and development	4,000
Total expenses	87,195	44,787
Loss from operations	(86,888)	(44,787)
Interest expense	(3,981)	(3,726)
Interest income	102	7
Net loss	$ (90,767)	$ (48,506)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (2.22)	$ (1.30)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	40,966	37,312
Comprehensive loss:
Net loss	$ (90,767)	$ (48,506)
Unrealized loss on pension obligation	(99)
Other comprehensive loss	(99)
Comprehensive loss	$ (90,866)	$ (48,506)