Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue
License revenue	$ 317
Expenses:
Cost of sales - intangible asset amortization	268
Research and development	155,390	$ 118,425	$ 75,725
Selling, general and administrative	78,701	23,935	14,780
Acquired in-process research and development	2,000	24,900	1,940
Total expenses	236,359	167,260	92,445
Loss from operations	(236,042)	(167,260)	(92,445)
Interest expense	(15,414)	(3,776)
Interest income	48	24	83
Net loss	$ (251,408)	$ (171,012)	$ (92,362)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (6.38)	$ (4.79)	$ (2.93)
Weighted-average number of common shares used in net loss per share applicable to common stockholders - basic and diluted (in shares)	39,387	35,739	31,559
Comprehensive loss	$ (251,408)	$ (171,012)	$ (92,362)