X0306 4 2016-09-08 0 0001491576 TESARO, Inc. TSRO 0001302600 English Edward C C/O TESARO, INC. 1000 WINTER STREET, SUITE 3300 WALTHAM MA 02451 0 1 0 0 V.P.Finance and Administration Common Stock, par value $.01 2016-09-08 4 M 0 3500 13.31 A 3500 D Common Stock, par value $.01 2016-09-08 4 M 0 3500 33.74 A 7000 D Common Stock, par value $.01 2016-09-08 4 S 0 5400 88.00 D 1600 D Common Stock, par value $.01 2016-09-08 4 S 0 100 88.98 D 1500 D Common Stock, par value $.01 2016-09-08 4 S 0 1500 90.47 D 0 D Employee Stock Option (right to buy) 13.31 2016-09-08 4 M 0 3500 0 D 2022-09-09 Common Stock 3500 6072 D Employee Stock Option (right to buy) 33.74 2016-09-08 4 M 0 3500 0 D 2024-02-27 Common Stock 3500 14500 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2015. The price reported is a weighted average. The shares were sold in multiple transactions at prices ranging from $87.52 to $88.35, inclusive. The reporting person undertakes to provide to TESARO, Inc., any security holder of TESARO, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. The price reported is a weighted average. The shares were sold in multiple transactions at prices ranging from $90.44 to $90.61, inclusive. The reporting person undertakes to provide to TESARO, Inc., any security holder of TESARO, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. A quarter of the original grant of options to purchase 28,672 shares of common stock vested on June 11, 2013 and, thereafter, 1/36th of the remaining options vested on each monthly anniversary of such date until fully vested. A quarter of the original grant of options to purchase 25,000 shares of common stock vested on February 27, 2015 and, thereafter, 1/36th of the remaining options vest on each monthly anniversary of such date until fully vested. /s/ Joseph L. Farmer, attorney-in-fact 2016-09-09