X0306 4 2016-06-01 0 0001491576 TESARO, Inc. TSRO 0001640861 Nicholson Garry A C/O TESARO, INC. 1000 WINTER STREET, SUITE 3300 WALTHAM MA 02451 1 0 0 0 Common Stock 2016-06-01 4 A 0 1269 0 A 1269 D Director Nonqualified Stock Option (right to buy) 47.27 2016-06-01 4 A 0 12000 0 A 2026-06-01 Common Stock 12000 12000 D The Reporting Person has elected to receive common stock in lieu of cash for board retainers and fees otherwise payable in cash. The option vests on the earlier of the one-year anniversary of the date of grant and the next annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the Issuer's board of directors. /s/ Joseph L. Farmer, Attorney-in-Fact 2016-06-03