Equity Investments - Additional Information (Details) - USD ($)	1 Months Ended			12 Months Ended
	Jul. 31, 2021	May 31, 2021	Jan. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Schedule of Equity Method Investments [Line Items]
Equity investments				$ 43,167,000	$ 45,664,000
Equity investments gains (losses)				(1,781,000)	4,108,000	$ 943,000
Distribution from equity investment				375,000	4,582,000	943,000
Proceeds from sale of equity investments				15,735,000
Cash payments to purchase of shares				3,700,000	2,869,000
Nimbus Therapeutics, LLC
Schedule of Equity Method Investments [Line Items]
Equity investments				0	0
Equity investments gains (losses)				0	(2,977,000)	(4,180,000)
Morphic Holding, Inc.
Schedule of Equity Method Investments [Line Items]
Equity investments				39,561,000	28,013,000
Equity investments gains (losses)				11,548,000	13,685,000	14,102,000
Petra Pharma Corporation
Schedule of Equity Method Investments [Line Items]
Distribution from equity investment		$ 4,582,000
Escrow payments receivable		361,000
Escrow payments received		$ 335,000
Ravenna Therapeutics
Schedule of Equity Method Investments [Line Items]
Equity investments gains (losses)				$ (75,000)	0	0
Common shares received in connection with merger				2,676,191
Carrying value of non-marketable equity securities				$ 19,000	94,000
Relay Therapeutics, Inc
Schedule of Equity Method Investments [Line Items]
Equity investments gains (losses)					17,556,000	$ 0
Proceeds from sale of equity investments			$ 15,735,000
Loss on sale of equity method investments				1,821,000
Ajax Therapeutics, Inc
Schedule of Equity Method Investments [Line Items]
Equity investments				1,700,000	0
Ajax Therapeutics, Inc | Series B Preferred Stock
Schedule of Equity Method Investments [Line Items]
Number of preferred shares purchased		631,377
Cash payments to purchase of shares		$ 1,700,000
ShouTi
Schedule of Equity Method Investments [Line Items]
Equity investments				1,887,000	$ 0
Equity investments gains (losses)				$ (113,000)
ShouTi | Series B Preferred Stock
Schedule of Equity Method Investments [Line Items]
Number of preferred shares purchased	494,035
Cash payments to purchase of shares	$ 2,000,000