X0306 4 2022-06-15 0 0001490978 Schrodinger, Inc. SDGR 0001797826 Thornberry Nancy C/O SCHRODINGER, INC., 1540 BROADWAY, 24TH FLOOR NEW YORK NY 10036 1 0 0 0 Stock Option (right to buy) 24.51 2022-06-15 4 A 0 14907 0.00 A 2032-06-15 Common Stock 14907 14907 D The option was granted on June 15, 2022. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. /s/ Donald Shum, as attorney-in-fact for Nancy Thornberry 2022-06-16