X0306 4 2021-10-15 0 0001490978 Schrodinger, Inc. SDGR 0001797672 Akinsanya Karen C/O SCHRODINGER, INC., 1540 BROADWAY, 24TH FLOOR NEW YORK NY 10036 0 1 0 0 See Remarks Common Stock 2021-10-15 4 M 0 1393 4.34 A 1393 D Common Stock 2021-10-15 4 S 0 1393 55.75 D 0 D Stock Option (right to buy) 4.34 2021-10-15 4 M 0 1393 0.00 D 2028-11-29 Common Stock 1393 43198 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021. This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022. EVP, Chief Biomedical Scientist, Head of Discovery R&D /s/ Donald Shum, as attorney-in-fact for Karen Akinsanya 2021-10-19