X0306 4 2021-09-13 0 0001490978 Schrodinger, Inc. SDGR 0001798179 Abel Robert Lorne C/O SCHRODINGER, INC., 1540 BROADWAY, 24TH FLOOR NEW YORK NY 10036 0 1 0 0 See Remarks Common Stock 2021-09-13 4 M 0 15602 17.00 A 15602 D Common Stock 2021-09-13 4 S 0 5820 61.0892 D 9782 D Common Stock 2021-09-13 4 S 0 9782 62.1443 D 0 D Stock Option (right to buy) 17.00 2021-09-13 4 M 0 15602 0.00 D 2030-02-05 Common Stock 15602 110357 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.65 to $61.58, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (3) of this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.73 to $62.63, inclusive. This option was granted on February 5, 2020. The shares underlying the option vested with respect to 25% of the shares on February 5, 2021 and the remainder are scheduled to vest in equal monthly installments through February 5, 2024. EVP, Chief Computational Scientist, Head of Modeling R&D /s/ Donald Shum, as attorney-in-fact for Robert Lorne Abel 2021-09-14