X0306 4 2021-06-17 0 0001490978 Schrodinger, Inc. SDGR 0001797826 Thornberry Nancy C/O SCHRODINGER, INC., 120 WEST 45TH STREET, 17TH FLOOR NEW YORK NY 10036 1 0 0 0 Stock Option (right to buy) 76.08 2021-06-17 4 A 0 8736 0.00 A 2031-06-17 Common Stock 8736 8736 D The option was granted on June 17, 2021. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. Exhibit 24.1 - Power of Attorney /s/ Donald Shum, as attorney-in-fact for Nancy Thornberry 2021-06-21