X0306 4 2021-06-14 0 0001490978 Schrodinger, Inc. SDGR 0001023870 SHAW DAVID E 120 WEST 45TH STREET, 39TH FLOOR NEW YORK NY 10036 0 0 1 0 0001801739 Schrodinger Equity Holdings, LLC 120 WEST 45TH STREET, 39TH FLOOR NEW YORK NY 10036 0 0 1 0 Common Stock, par value $0.01 per share 2021-06-14 4 S 0 8911 76.4976 D 7436511 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-14 4 S 0 31512 77.7167 D 7404999 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-14 4 S 0 3040 78.3397 D 7401959 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-15 4 S 0 8723 73.3808 D 7393236 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-15 4 S 0 37365 74.1026 D 7355871 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-15 4 S 0 13826 74.8377 D 7342045 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-15 4 S 0 500 75.86 D 7341545 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-16 4 S 0 8229 73.3367 D 7333316 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-16 4 S 0 19107 74.3979 D 7314209 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-06-16 4 S 0 9859 75.1219 D 7304350 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 4264 I Held by D. E. Shaw Technology Development, LLC The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $76.165 to $77.15, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $77.17 to $78.13 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $78.20 to $78.35, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.69 to $73.68, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.69 to $74.68, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.69 to $75.28, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.77 to $73.765, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.775 to $74.76, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.78 to $75.49, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. David E. Shaw is President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the sole member of D. E. Shaw Technology Development, LLC. David E. Shaw, By: /s/ Zach Bendiner, as Attorney-in-Fact for David E. Shaw 2021-06-16 Schrodinger Equity Holdings, LLC, By: /s/ Zach Bendiner, Authorized Signatory 2021-06-16