X0306 4 2021-05-12 0 0001490978 Schrodinger, Inc. SDGR 0001023870 SHAW DAVID E 120 WEST 45TH STREET, 39TH FLOOR NEW YORK NY 10036 0 0 1 0 0001801739 Schrodinger Equity Holdings, LLC 120 WEST 45TH STREET, 39TH FLOOR NEW YORK NY 10036 0 0 1 0 Common Stock, par value $0.01 per share 2021-05-12 4 S 0 9981 59.619 D 7662899 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-12 4 S 0 9671 60.4617 D 7653228 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-12 4 S 0 5048 61.3475 D 7648180 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-12 4 S 0 300 62.33 D 7647880 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-13 4 S 0 5774 58.1006 D 7642106 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-13 4 S 0 9282 58.8247 D 7632824 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-13 4 S 0 1570 60.1917 D 7631254 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-13 4 S 0 3329 61.0633 D 7627925 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-13 4 S 0 5045 61.7763 D 7622880 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-14 4 S 0 2800 58.341 D 7620080 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-14 4 S 0 2213 59.5135 D 7617867 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-14 4 S 0 14803 60.5126 D 7603064 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-05-14 4 S 0 5184 61.1553 D 7597880 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 4264 I Held by D. E. Shaw Technology Development, LLC The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $58.98 to $59.96, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $59.99 to $60.97, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $60.99 to $61.85, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $62.11 to $62.50, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $57.39 to $58.38, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $58.39 to $59.295, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $59.46 to $60.45, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $60.47 to $61.46, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $61.48 to $62.435, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $57.84 to $58.79, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $58.99 to $59.98, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $59.99 to $60.985, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $60.99 to $61.36, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. David E. Shaw is President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the sole member of D. E. Shaw Technology Development, LLC. David E. Shaw, By: /s/ Charles Ardai, as Attorney-in-Fact for David E. Shaw 2021-05-14 Schrodinger Equity Holdings, LLC, By: /s/ Charles Ardai, Authorized Signatory 2021-05-14