X0306 4 2021-03-16 0 0001490978 Schrodinger, Inc. SDGR 0001797782 Weiser Jorg C/O SCHRODINGER, INC., 120 WEST 45TH STREET, 17TH FLOOR NEW YORK NY 10036 0 1 0 0 EVP & Managing Director Common Stock 2021-03-16 4 M 0 18095 3.07 A 181511 D Common Stock 2021-03-16 4 S 0 18095 82.00 D 163416 D Common Stock 2021-03-16 4 M 0 6527 4.34 A 169943 D Common Stock 2021-03-16 4 S 0 6527 82.00 D 163416 D Common Stock 2021-03-16 4 S 0 37060 82.00 D 126356 D Common Stock 2021-03-17 4 S 0 6600 78.0723 D 119756 D Common Stock 2021-03-17 4 S 0 1500 79.6988 D 118256 D Common Stock 2021-03-17 4 S 0 904 80.8483 D 117352 D Common Stock 2021-03-17 4 S 0 300 81.33 D 117052 D Common Stock 17390 I BY ANTERIO CONSULT AND RESEARCH GMBH Stock Option (right to buy) 3.07 2021-03-16 4 M 0 18095 0.00 D 2026-05-10 Common Stock 18095 0 D Stock Option (right to buy) 4.34 2021-03-16 4 M 0 6527 0.00 D 2028-11-29 Common Stock 6527 9614 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 1, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $77.73 to $78.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (4) of this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $79.25 to $80.18, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.32 to $81.31, inclusive. The shares are beneficially owned by Anterio Consult & Research GmbH ("Anterio"). Dr. Weiser is a shareholder and former managing director of Anterio and disclaims beneficial ownership of the shares held by Anterio, except to the extent of his pecuniary interest therein, if any. The option was granted on May 11, 2016 and is fully vested. This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022. /s/ Donald Shum, as attorney-in-fact for Jorg Weiser 2021-03-18