X0306 4 2021-03-11 0 0001490978 Schrodinger, Inc. SDGR 0001798426 Friesner Richard C/O SCHRODINGER, INC., 120 WEST 45TH STREET, 17TH FLOOR NEW YORK NY 10036 1 0 0 0 Common Stock 2021-03-11 4 S 0 12000 80.2815 D 504450 D Common Stock 2021-03-11 4 S 0 20000 80.4602 D 694925 I By grantor retained annuity trust Common Stock 28328 I By Spouse These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 24, 2020 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.00 to $80.74, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (3). The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.00 to $80.96, inclusive. These shares are owned directly by the RF 2018 GRAT (the "Trust"), a grantor retained annuity trust, and indirectly by Mr. Friesner as trustee and sole annuitant of the Trust. /s/ Donald Shum, as attorney-in-fact for Richard Friesner 2021-03-12