X0306 4 2021-03-08 0 0001490978 Schrodinger, Inc. SDGR 0001798426 Friesner Richard C/O SCHRODINGER, INC., 120 WEST 45TH STREET, 17TH FLOOR NEW YORK NY 10036 1 0 0 0 Common Stock 2021-03-08 4 S 0 3942 64.5517 D 536508 D Common Stock 2021-03-08 4 S 0 2210 65.5284 D 534298 D Common Stock 2021-03-08 4 S 0 3784 66.4518 D 530514 D Common Stock 2021-03-08 4 S 0 1164 67.5962 D 529350 D Common Stock 2021-03-08 4 S 0 700 68.4857 D 528650 D Common Stock 2021-03-08 4 S 0 200 69.615 D 528450 D Common Stock 2021-03-09 4 S 0 12000 70.0658 D 516450 D Common Stock 2021-03-08 4 S 0 5178 64.4112 D 749747 I By grantor retained annuity trust Common Stock 2021-03-08 4 S 0 5133 65.3995 D 744614 I By grantor retained annuity trust Common Stock 2021-03-08 4 S 0 6208 66.435 D 738406 I By grantor retained annuity trust Common Stock 2021-03-08 4 S 0 1810 67.5531 D 736596 I By grantor retained annuity trust Common Stock 2021-03-08 4 S 0 1200 68.382 D 735396 I By grantor retained annuity trust Common Stock 2021-03-08 4 S 0 471 69.4397 D 734925 I By grantor retained annuity trust Common Stock 2021-03-09 4 S 0 15184 70.0776 D 719741 I By grantor retained annuity trust Common Stock 2021-03-10 4 S 0 4816 72.3729 D 714925 I By grantor retained annuity trust Common Stock 28328 I By spouse These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 24, 2020 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.08 to $65.07, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (9) and footnotes (11) through (17) of this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.08 to $66.05, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.10 to $66.97, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.10 to $68.00, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.19 to $69.05, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.44 to $69.79, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.00 to $70.57, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.01 to $64.74, inclusive. These shares are owned directly by the RF 2018 GRAT (the "Trust"), a grantor retained annuity trust, and indirectly by Mr. Friesner as trustee and sole annuitant of the Trust. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.01 to $66.00, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.02 to $66.92, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.06 to $68.01, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.06 to $68.95, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.17 to $69.79, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.00 to $70.73, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $71.97 to $72.91, inclusive. Prior reports filed by the reporting person understated the number of shares beneficially owned by the reporting person by failing to report the shares held by the reporting person's spouse. Exhibit 24.1 - Power of Attorney /s/ Donald Shum, as attorney-in-fact for Richard Friesner 2021-03-10