X0306 4 2021-02-22 0 0001490978 Schrodinger, Inc. SDGR 0001023870 SHAW DAVID E 120 WEST 45TH STREET, 39TH FLOOR NEW YORK NY 10036 0 0 1 0 0001801739 Schrodinger Equity Holdings, LLC 120 WEST 45TH STREET, 39TH FLOOR NEW YORK NY 10036 0 0 1 0 Common Stock, par value $0.01 per share 2021-02-22 4 S 0 2701 110.3529 D 9312882 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-22 4 S 0 8534 111.2353 D 9304348 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-22 4 S 0 33292 112.4353 D 9271056 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-22 4 S 0 106067 113.309 D 9164989 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-22 4 S 0 75066 114.3284 D 9089923 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-22 4 S 0 33998 115.2471 D 9055925 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-22 4 S 0 16592 115.9477 D 9039333 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 2572 100.4712 D 9036761 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 916 101.6703 D 9035845 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 3303 102.9877 D 9032542 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 7827 103.6481 D 9024715 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 7832 104.6773 D 9016883 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 7434 105.6912 D 9009449 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 13503 106.5428 D 8995946 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 8211 107.8371 D 8987735 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 12436 108.7633 D 8975299 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-23 4 S 0 966 109.3207 D 8974333 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 7059 107.4149 D 8967274 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 2908 108.6741 D 8964366 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 7388 109.6948 D 8956978 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 20766 110.8423 D 8936212 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 22118 111.4856 D 8914094 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 20178 112.5224 D 8893916 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 7103 113.3954 D 8886813 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 26872 114.7897 D 8859941 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 2021-02-24 4 S 0 2051 115.4432 D 8857890 I Held by Schrodinger Equity Holdings, LLC Common Stock, par value $0.01 per share 4264 I Held by D. E. Shaw Technology Development, LLC The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $109.75 to $110.74, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $110.755 to $111.73, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $111.795 to $112.79, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $112.80 to $113.79, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $113.80 to $114.785, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $114.80 to $115.795, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $115.80 to $116.77, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $100.05 to $101.04, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $101.18 to $102.17, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $102.18 to $103.17, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $103.19 to $104.18, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $104.20 to $105.16, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $105.20 to $106.19, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $106.20 to $107.14, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $107.20 to $108.17, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $108.23 to $109.22, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $109.25 to $109.40, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $107.01 to $107.80, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $108.05 to $109.03, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $109.06 to $110.03, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $110.10 to $111.09, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $111.10 to $112.09, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $112.10 to $113.095, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $113.13 to $114.09, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $114.20 to $115.19, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $115.20 to $115.745, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. David E. Shaw is President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the sole member of D. E. Shaw Technology Development, LLC. David E. Shaw, By: /s/ Charles Ardai, as Attorney-in-Fact for David E. Shaw 2021-02-24 Schrodinger Equity Holdings, LLC, By: /s/ Charles Ardai, Authorized Signatory 2021-02-24