X0306 4 2020-11-24 0 0001490978 Schrodinger, Inc. SDGR 0001166559 BILL & MELINDA GATES FOUNDATION TRUST 2365 CARILLON POINT KIRKLAND WA 98033 0 0 1 0 Common stock 2020-11-24 4 C 0 4000000 A 8981664 D Common stock 2020-11-24 4 S 0 2000000 63.50 D 6981664 D Limited common stock 2020-11-24 4 C 0 4000000 D Common stock 4000000 9164193 D All shares of the Issuer's limited common stock have no expiration date and may be exchanged at the election of Bill & Melinda Gates Foundation Trust into the Issuer's common stock on a 1-for-1 basis without payment of further consideration. Exempt from the operations of Section 16(b) of the Securities Exchange Act of 1934, as amended, pursuant to Rule 16b-6(b) thereunder. Bill & Melinda Gates Foundation Trust By: /s/ Alan Heuberger, Attorney-in-fact for each of the Co-Trustees, William H. Gates III and Melinda French Gates 2020-11-27