X0306 4 2020-06-11 0 0001556263 Syros Pharmaceuticals, Inc. SYRS 0001490283 Young Richard A C/O SYROS PHARMACEUTICALS, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 1 0 0 0 Stock Option (right to buy) 9.17 2020-06-11 4 A 0 17500 0.00 A 2030-06-10 Common Stock 17500 17500 D The option becomes exercisable as to 50% of the shares underlying the award on the six month anniversary of the date of grant, with the remainder vesting in equal monthly installments until the first anniversary of the date of grant, subject to the reporting person's continued service as a director through each applicable vesting date. /s/ Gerald E. Quirk, as attorney-in-fact 2020-06-11