<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0705</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001488790</cik>
        <entityName>Cold Plasma Medical Technologies, Inc.</entityName>
        <issuerAddress>
            <street1>8502 EAST PRINCESS DRIVE, SUITE 210</street1>
            <city>SCOTTSDALE</city>
            <stateOrCountry>AZ</stateOrCountry>
            <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
            <zipCode>85255</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>623-537-5644</issuerPhoneNumber>
        <jurisdictionOfInc>NEVADA</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2010</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DAVID</firstName>
                <middleName>J</middleName>
                <lastName>JACOFSKY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>CHIEF EXECUTIVE OFFICER</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ROBERT</firstName>
                <middleName>M</middleName>
                <lastName>HUMMEL</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>CHIEF OPERATING OFFICER</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>GREGORY</firstName>
                <middleName>A</middleName>
                <lastName>WATSON</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>CHIEF TECHNOLOGY OFFICER</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>MARC</firstName>
                <middleName>C</middleName>
                <lastName>JACOFSKY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>CHIEF SCIENTIFIC OFFICER</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ROBERT</firstName>
                <lastName>TAGGART</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>EXECUTIVE VICE PRESIDENT OF BUSINESS DEVELOPMENT</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RONALD</firstName>
                <middleName>D</middleName>
                <lastName>ROBINSON</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>KEVIN</firstName>
                <middleName>P</middleName>
                <lastName>MCDOWELL</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>STEPHEN</firstName>
                <middleName>A</middleName>
                <lastName>BRIGIDO</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RON</firstName>
                <lastName>LAWSON</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8502 EAST PRINCESS DRIVE</street1>
                <street2>SUITE 210</street2>
                <city>SCOTTSDALE</city>
                <stateOrCountry>AZ</stateOrCountry>
                <stateOrCountryDescription>ARIZONA</stateOrCountryDescription>
                <zipCode>85255</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2012-06-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1000000</totalOfferingAmount>
            <totalAmountSold>1000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Cold Plasma Medical Technologies, Inc.</issuerName>
                <signatureName>DAVID J. JACOFSKY</signatureName>
                <nameOfSigner>DAVID J. JACOFSKY</nameOfSigner>
                <signatureTitle>CEO</signatureTitle>
                <signatureDate>2012-06-26</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
