Commitments and Contingencies - Additional Information (Detail)				1 Months Ended			12 Months Ended
	Sep. 30, 2016 USD ($) ft²	Apr. 18, 2016 USD ($) ft²	Mar. 11, 2015 USD ($)	Sep. 30, 2016 USD ($) ft²	Sep. 30, 2013 USD ($)	Jul. 31, 2013	Dec. 31, 2016 USD ($) $ / ft²	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Jun. 30, 2015 USD ($)	Jun. 30, 2014 USD ($) ft²	Dec. 31, 2013 ft²
Long-term Purchase Commitment [Line Items]
Period of supply agreement						5 years
Supply agreement amended date							2016-10
Minimum remaining purchase commitment							$ 6,508,000
Bluebird [Member]
Long-term Purchase Commitment [Line Items]
Lease agreement effective date							May 01, 2017
ARE Lease [Member] | ARE-7030 Kit Creek, LLC [Member]
Long-term Purchase Commitment [Line Items]
Area of office and laboratory space under lease agreement | ft²		48,236
Lease rent abatement period							9 months
Lease expiration date							Jan. 31, 2022
Option to extend lease term							10 years
Rent expense associated with the lease							$ 675,000
Lease rent per month		$ 86,423
Lease agreement start date							Apr. 18, 2016
Increase in annual lease rent, percentage		3.00%
ARE Lease [Member] | ARE-7030 Kit Creek, LLC [Member] | Maximum [Member]
Long-term Purchase Commitment [Line Items]
Tenant improvements to leased space		$ 1,205,900
Penzberg, Germany Lease [Member] | Roche Diagnostics, GmbH [Member]
Long-term Purchase Commitment [Line Items]
Lease expiration date							Sep. 08, 2021
Option to extend lease term							2 years
Lease agreement start date							Sep. 09, 2016
150 Second Street [Member]
Long-term Purchase Commitment [Line Items]
Area of office and laboratory space under lease agreement | ft²												61,591
Lease expected term							8 years
Lease rent waiver period							10 months 15 days
Value of rent obligations					$ 3,300,000
Security deposit of lease agreement					1,725,000				$ 864,000
Tenant improvements					$ 9,239,000
Amended lease expected term							7 years 6 months
Percentage of monthly base rent receivable on delay in surrender of lease							100.00%
Rent expense associated with the lease							$ 2,534,000	$ 2,534,000	$ 2,411,000
150 Second Street [Member] | Second Amendment [Member]
Long-term Purchase Commitment [Line Items]
Tenant improvements											$ 1,020,500
Additional space for lease | ft²											8,164
Lease commencement date							2014-11
150 Second Street [Member] | Third Amendment [Member]
Long-term Purchase Commitment [Line Items]
Area of office and laboratory space under lease agreement | ft²	123,210			123,210
Security deposit of lease agreement							$ 1,771,009
Lease rent abatement period							2 months
Lease expiration date							Apr. 30, 2024
Option to extend lease term							5 years
150 Second Street [Member] | Third Amendment [Member] | Maximum [Member]
Long-term Purchase Commitment [Line Items]
Tenant improvements to leased space	$ 2,500,000
Annual base rent payable per square foot | $ / ft²							83.42
150 Second Street [Member] | Third Amendment [Member] | Minimum [Member]
Long-term Purchase Commitment [Line Items]
Annual base rent payable per square foot | $ / ft²							70.51
150 Second Street [Member] | Third Amendment [Member] | Bluebird [Member]
Long-term Purchase Commitment [Line Items]
Area of office and laboratory space surrendered under lease agreement | ft²	53,455			53,455
150 Second Street [Member] | Bluebird Premises [Member] | Maximum [Member]
Long-term Purchase Commitment [Line Items]
Annual base rent payable per square foot | $ / ft²							72.84
150 Second Street [Member] | Bluebird Premises [Member] | Minimum [Member]
Long-term Purchase Commitment [Line Items]
Annual base rent payable per square foot | $ / ft²							62.83
One Kendall Square [Member]
Long-term Purchase Commitment [Line Items]
Rent abatement							$ 1,841,000
Ten Canal Park Lease [Member]
Long-term Purchase Commitment [Line Items]
Security deposit of lease agreement			$ 1,037,000							$ 530,550
Tenant improvements to leased space			1,995,550
Lease expiration date							Aug. 31, 2020
Rent expense associated with the lease							$ 1,630,000	$ 1,279,000
Lease rent per month			$ 172,850
Penzberg, Germany Lease [Member] | Roche Diagnostics, GmbH [Member]
Long-term Purchase Commitment [Line Items]
Rent expense associated with the lease							$ 79,000
Lease rent per month				$ 22,000
Increase in annual lease rent, percentage	2.00%